Regine is from Philadelphia, PA. Her acting career took off after an appearance in Grey's Anatomy. From there she starred in various movies with hit actors such as Bernie Mac in Pride, Mila Kunis in Boot Camp, and Chris Rock and Martin Lawrence in Death at a Funeral. Regine has also featured in the movie Crazy Eyes.
Some of Regine's most noteworthy apprearences include when she starred as Samuel L. Jackson's daughter, Celia Turner, in the suspenseful thriller film Lakeview Terrace, Jacquie in the MTV film Super Sweet Sixteen: The Movie and as Willie, the only female swimmer in the movie Pride.